Apheresis

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Apheresis

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Kaneka

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Apheresis is Greek and means removal

Plasma-apheresis is partially removing plasma from cellular components of the blood. Lipid-apheresis is a procedure for separating lipids out of plasma or whole blood.

It is an “extracorporeal” (blood taken outside the body) procedure to remove apoB (apolipoprotein B) containing lipids such as LDL (Low Density Lipoprotein, usually referred as “bad cholesterol”), VLDL (Very Low Density Lipoprotein) and Lp(a) (Lipoprotein a) from the blood or plasma.

This treatment is used for high risk patients with elevated LDL-cholesterol and Lp(a) levels who are refractory to established drug therapy.

Immune apheresis is targeting the removal of auto-antibodies and immuno-complexes out of plasma. This therapy is indicated for patients with auto-immune diseases or as well for antibody mediated transplant rejection.

Lipid-apheresis procedure applies after both dietary and drug treatments have been inefficient. The patients treated by lipid-apheresis have high elevated LDL-cholesterol level, such as in Familiar Hypercholesterolemia, and/or are patients with elevated Lp(a).

Kaneka’s lipid-apheresis treatment is using an adsorption column to eliminate LDL and Lp(a) particles from blood or plasma. This adsorption column is called Liposorber®.

The adsorber material of the Liposorber® contains negatively charged dextran sulfate bound on cellulose beads distinguished by:

  • A selective reduction of positively charged apo B-containing lipoproteins for patients
    suffering from elevated LDL and Lp(a) levels
  • HDL cholesterol and other plasma components are mainly preserved

During Kaneka’s lipid-apheresis treatment the patient’s blood circulates outside the body through the Liposorber® dextran sulfate column where it effectively removes LDL and Lp(a) from the blood or plasma and thereafter returns to the patient.

This can be done:

  1. directly by whole blood treatment
  2. by plasma treatment after plasma separation

Kaneka’s lipid-apheresis treatment consists of disposable components which are discarded after each lipid-apheresis treatment.